TABEX EFFECTIVE, SAFE AND FAST TO STOP SMOKING!
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Tabex is an original Bulgarian preparation of plant origin, intended for the treatment of tobacco smoking. The preparation is developed on the basis of the alkaloid Cytisine, contained in the plant Cytisus laborinum L. (Golden Rain acacia).
The broad clinical studies carried out, show that the therapy with the preparation Tabex results in giving up smoking in more than 57% of the patients.
In the human body, Cytisine plays the role of nicotine substitution substance, and reduces the period of interaction of the received nicotine with relevant nicotine receptors, i.e. the specific substance cytisine "substitutes" nicotine, acting on the same receptors, thus preventing the appearance of abstinence syndrome. This results in a gradual reduction and suspension of the psychic and physical dependency to nicotine in smokers.
Cytisine possesses a structure and mechanism of action that are similar to those of nicotine, but it has much lower toxicity.
Tabex manifests one of the best results to date for the group of preparations, intended for tobacco smoking therapy.
Tabex is very well tolerated, and when applied in therapeutic doses, allows a gradual giving up of smoking without any side effects.
The total giving up of smoking should take place not later than the fifth day after the beginning of the therapy. Supplied in a package of 100 filmtablets of 1.5 mg Citysine
Active ingredient: Cytisine
Drug form: Filmtablets of 1.5 mg Cytisine
Composition: One filmtablet contains 1.5 mg Cytisine
Active substance: Cytisine 1.5 mg
Other ingredients: Calcium dihydrogenphosphate, Lactose, Wheat starch, Microcrystalline cellulose, Talc, Magnesium stearate.
Pharmaco-therapeutic group: Vegetotropic agent - N- cholinomimetic (gangliostimulant).
Indications: Chronic nicotinism (tabacosis) - for breaking the habit of smoking.
Contraindications: Tabex is contraindicated in arterial hypertension and advanced atherosclerosis.
Warning:The clinical studies with Tabex show that the Bulgarian drug is effective and well tolerated. The adverse effects are insignificant in case of adequate treatment according to the schedule and do not necessitate reduction of the dose and shortening the duration of the treatment. The physicians should warn the patients that the simultaneous administration of the drug and smoking could lead to aggravated adverse effects of nicotine (nicotine intoxication). The drug should be used in all cases when the patient has a honest and firm intention to give up smoking.
There is not sufficient clinical experience with Tabex administration to patients with ischemic heart disease, cardiac impairment, cerebrovascular diseases, obliterating arterial diseases, hyperthyroidism, diabetes mellitus, renal and hepatic insufficiency. The use of the drug of these categories of patients should be performed only after the potential benefit has been weighed against the possible risks.
Pregnancy and lactation: The intraovular application of Cytisine substance to hen embryos induced no embriotoxic and teratogenic effect within the limits of the single therapeutic doses. Higher doses of the drug lead to embryotoxic action. On the base of the experimental data obtained, Tabex is recommended (with Cytisine as the basic component) not to be taken by pregnant women, due to the potential risk of embryotoxic action in case of uncontrolled administration. The drug should not be administered during breast feeding.
Effect of the drug on drivers and machine operators: Tabex is considered safe and induces no changes in the physchophysical status, driving ability and machine operation.
Drug interactions: No data is available on undesired interactions between Tabex and other pharmaceuticals.
Overdose: Symptoms of nicotine intoxication are observed in Tabex overdose. The toxic effects are manifested in nausea, vomiting, pupil dilation, tachycardia, general weakness, clonic convulsions, paralysis of respiration. The communications of overdose with the drug are scarce. Lavage of the stomach, monitoring of respiration, arterial pressure and heart rate are initiated as in all cases of overdose. Infusion, reanimation is undertaken with saline and glucose solutions, anticonvulsants, cardiotonics, analeptics, etc. symptomatic agents.
Administration and dosage: The drug is administered perorally according to the following schedule:
First 3 days: 1 tablet 6 times daily (every 2 hours) with a parallel reduction of the number of cigarettes smoked.
If the result is unsatisfactory, the treatment is discontinued and a new therapy can be resumed after 2-3 months. In case of good effect, the treatment should continue according to the following schedule:
Smoking cessation should occur by the 5th day after the initiation of the treatment. After the end of the therapeutic course, in order to have good results, the patient should give evidence of strong will, not allowing the lighting of a cigarette.
Undesired adverse effects: The clinical studies showed a good tolerance to the drug and grave adverse effects were not observed. The following adverse effects are rather often observed at the beginning of Tabex treatment: changes in both taste and appetite, dryness in the mouth, headache, irritability, nausea, constipation, tachycardia, light elevation of the arterial pressure. The majority of the adverse effects can abate in the course of the treatment.
Storage: In original packages, in dry, and light-protected premises at temperature of 15° -25° C (60° - 75° F)
Expiry term: Two year from manufacture date